Environmental nitrosamines and cancer
نویسندگان
چکیده
منابع مشابه
Relevance of nitrosamines to human cancer.
It is now about three decades since the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA)* was demonstrated in rats (1) and the suggestion was made that N-nitrosamines can be formed following nitrosation of various amines (2). Direct proof that such nitrosation reactions can occur was provided by Ender et al. (3) who identified NDMA in nitrite preserved fish-meal, and by Sander and Sei...
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A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabli...
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A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...
متن کاملNitrosamines and nitramines
2. Furthermore, NIPH was asked by Klif to evaluate existing risk estimates for Nnitrosodimethylamine (NDMA). This includes an evaluation of EPA/IRIS risk estimates for drinking water and air, and other risk estimates of this nitrosamine in Europe or Canada. Klif wanted an evaluation of the validity of the values, how they can be used, and how they should be interpreted. NIPH was also asked to c...
متن کاملTobacco-specific nitrosamines, hemoglobin adducts and exposure to environmental tobacco smoke
Hemoglobin (Hb) adducts of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB), a metabolite of two tobacco-specific nitrosamines: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N’nitrosonornicotine (NNN), were measured in blood samples collected from 47 non-smokers, including 21 cases of lung cancer, enrolled in four centers. Exposure to environmental tobacco smoke (ETS) during the previous yea...
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ژورنال
عنوان ژورنال: Nature
سال: 1981
ISSN: 0028-0836,1476-4687
DOI: 10.1038/294694a0